Increasing volumes of complex genomic data presents significant challenges in interpreting results and communicating findings. However, interactive engagement with these data can facilitate more robust data exploration and analysis and provide a platform to easily communicate complex data to key stakeholders. Recent advances in web frameworks and libraries have enabled the creation of complex, yet efficient client-side applications. The development of these frameworks has enabled the production of feature-rich, self-contained interactive single file reports (SCIFRs) that combine the benefits of rapid web development with extensive library support. Here, we present a novel web development approach to generate the SCIFRs and integrate them with existing bioinformatics tools or pipelines. Our SCIFRs development workflow, referred to as SCIFR-flow, facilitates rapid production of self-contained and fully interactive HTML that are embeddable and easy to share. The utility of SCIFR-flow has been demonstrated through the development of a single file interactive genome comparison tracks tool, a command-line tool designed for comparing multiple genomes and presenting results in an interactive file. The boilerplate codes and template files for these tools are described at https://thesfirs.fordelab.com and are available at https://github.com/nalarbp/scifr-flow.